Comparative analysis of methods for determination of protein binding sites

Mirceva, Georgina and Naumoski, Andreja and Kulakov, Andrea (2017) Comparative analysis of methods for determination of protein binding sites. In: PROCEEDINGS of the 14th Conference on Informatics and Information Technology. Faculty of Computer Science and Engineering, Ss. Cyril and Methodius University in Skopje, Macedonia, Skopje, Macedonia, pp. 163-164. ISBN 978-608-4699-07-1

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Abstract

Proteins are very important since they participate in many processes in the organisms. They effect these processes by performing particular functions. Therefore, it is very useful if we know the functions of proteins, so we can regulate the processes in the cells. The literature provides lots of methods for determinations of protein functions, but still there is a large gap between the known protein structures and those for which we know its functions. One way to determine the protein functions is to analyze the characteristics of protein binding sites where protein interaction happens. In this paper, we focus on determination of protein binding sites. We present an approach for protein binding sites prediction. Our approach considers the geometrical conformation of protein structures, and by using classification method, it identifies the atoms that are part of binding region. We present some results from the comparison with several approaches that are widely used.

Item Type: Book Section
Subjects: International Conference on Informatics and Information Technologies > Artificial Intelligence
International Conference on Informatics and Information Technologies > Robotics
International Conference on Informatics and Information Technologies > Bioinformatics
Depositing User: Vangel Ajanovski
Date Deposited: 29 Nov 2017 18:30
Last Modified: 29 Nov 2017 18:30
URI: http://eprints.finki.ukim.mk/id/eprint/11396

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